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据Braun GB 2014年6月8日(Nat Mater,2014 Jun 8.doi:10.1038/nmat3982.)报道,美国加州大学圣巴巴拉分校的研究人员通过研究设计出了一种新型的球状纳米颗粒,其主要由银组成,球状表面包被着一层肽,可以使其对肿瘤细胞进行靶向作用;这种新型纳米颗粒的外壳和内容物并不可拆分,因此不能靶向攻击肿瘤细胞的纳米颗粒就不会被消除和破坏掉。移除不能渗透靶向细胞的纳米颗粒的方法是特殊的,通过对那些可以进入到细胞的银纳米颗粒进行研究,就可以揭示哪些细胞可以被靶向作用,以及更清楚地解析纳米粒子在组织中的运输路径。有些药物本身就具有穿过细胞膜的特性,但是许多药物,尤其是RNA和DNA的遗传药物,其往往是带电荷的分子,可以被细胞膜所阻断,而其进入细胞内的方法无非是通过细胞吞噬作用
According to a report by Braun GB on June 8, 2014 (Nat Mater, 2014 Jun 8. doi: 10.1038 / nmat3982.), Researchers at the University of California, Santa Barbara, designed a novel type of spherical nanoparticle Mainly composed of silver, the globular surface coated with a layer of peptides that allows targeting of tumor cells; the outer shell and contents of this new nanoparticle are not separable and therefore can not target the nanoparticles that attack the tumor cells Will not be eliminated and destroyed. The method of removing nanoparticles that can not penetrate the targeted cells is special, and by studying those silver nanoparticles that can enter the cells, one can reveal which cells can be targeted and clearer the resolution of the nanoparticles in the tissue In the transport path. Some drugs have the property of traversing the cell membrane themselves, but many drugs, especially genetic drugs for RNA and DNA, are often charged molecules that can be blocked by the cell membrane and enter the cell simply by passing through the cell Phagocytosis