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目的探讨组织多普勒Tei指数评价胸部放疗,对肿瘤患者心功能影响的临床应用价值。方法将80例患者依据是否联合化疗分为单纯放疗组(A组),放疗联合化疗组(B组);按放疗进程,分别于放疗前、放疗3周、放疗5周对所有观察对象进行左心室射血分数(LVEF)、左、右心室及组织多普勒Tei指数的测量。结果放疗3周时,与放疗前比较,A组LVEF、左、右心室T ei指数差异均无统计学意义(P>0.05);B组LVEF差异无统计学意义(P>0.05),左、右心室Tei指数升高(P<0.05)。放疗5周时,A、B两组LVEF较放疗前比较差异均无统计学意义(P>0.05),左、右心室Tei指数均升高(P<0.01)。放疗后,A、B两组的左、右心室Tei指数比较差异均无统计学意义(P>0.05)。结论组织多普勒Tei指数是评价胸部放疗导致早期心功能损害的敏感指标,左、右心室功能损害程度无明显差异,放疗联合应用化疗可加重心脏损害。
Objective To investigate the clinical value of Tissue Doppler Tei index in evaluating the cardiac function of patients with thoracic radiotherapy. Methods Eighty patients were divided into radiotherapy group (group A) and radiotherapy combined with chemotherapy group (group B) according to whether chemotherapy combined with radiotherapy or not. All patients were treated with radiotherapy for three weeks before radiotherapy and five weeks after radiotherapy Ventricular ejection fraction (LVEF), left and right ventricular and tissue Doppler Tei index measurements. Results Compared with those before radiotherapy, there was no significant difference in T ei index of LVEF, left ventricle and right ventricle in group A at 3 weeks (P> 0.05). There was no significant difference in LVEF between group B and group B (P> 0.05) Right ventricular Tei index increased (P <0.05). At 5 weeks after radiotherapy, there was no significant difference in LVEF between groups A and B before radiotherapy (P> 0.05), and Tei index of left and right ventricles were all increased (P <0.01). After radiotherapy, there was no significant difference in Tei index of left and right ventricle between groups A and B (P> 0.05). Conclusion Tissue Doppler Tei index is a sensitive index to evaluate the early cardiac function damage caused by chest radiotherapy. There is no significant difference in left and right ventricular dysfunction. Radiotherapy combined with chemotherapy can aggravate heart damage.