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目的 :观察鼻腔恶性黑色素瘤临床病理特征 ,探索提高其诊断准确率的要领。方法 :对 11例恶性黑色素瘤病例 ,用 HE染色、黑色素染色 (Fontana- Masson法 )、免疫组织化学 (SP法 )进行检测。结果 :结合形态及组织化学或免疫组化的病理诊断较容易 ,临床误诊为息肉高达 6 3.6 % (7/ 11) ;因病变晚期及结合 CT有骨质密度改变甚至骨质破坏而诊断准确者占 4/ 11。结论 :灰黑色息肉样外观是鼻腔恶性黑色素瘤的特征 ,结合 CT可提高其诊断准确率。
Objective: To observe the clinicopathological features of nasal malignant melanoma and to explore ways to improve its diagnostic accuracy. Methods: Eleven cases of malignant melanoma were examined by HE staining, Fontana-Masson staining and immunohistochemistry (SP method). Results: The histopathology and histochemistry or immunohistochemistry were easier to diagnose. The polyps were misdiagnosed as 6 3.6% (7/11) in clinic. The diagnosed patients were diagnosed correctly because of the change of bone density or even the bone destruction Accounting for 4/11. Conclusion: The appearance of gray-black polyp is a characteristic of malignant melanoma in nasal cavity. Combined with CT, it can improve the diagnostic accuracy.