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基质金属蛋白酶-9(MMP-9)是一种Zn~(2+)依赖性蛋白水解酶,能降解和重塑细胞外基质,破坏血脑屏障,介导炎症反应,促进神经细胞死亡,同时也有利于运动功能的恢复。MMP-9激活和调控与神经系统疾病的发病机制有密切的关系。MMP-9是研究过程中发现的新靶点,为神经系统疾病的早期诊断、并发症的预防和治疗开辟了新的途径,为神经系统疾病患者的治疗带来曙光。
Matrix metalloproteinase-9 (MMP-9) is a Zn2 + -dependent proteolytic enzyme that degrades and remodels the extracellular matrix, destroys the blood-brain barrier, mediates inflammatory responses, and promotes neuronal cell death, Also conducive to the recovery of motor function. MMP-9 activation and regulation and the pathogenesis of nervous system diseases are closely related. MMP-9 is a new target discovered in the research process, which opens up new avenues for the early diagnosis of neurological diseases and the prevention and treatment of complications, bringing a ray of hope for the treatment of patients with nervous system diseases.