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目的:分析D-二聚体对急性心肌梗死(AMI)危险程度及预后预测的价值。方法:选取我院2012年5月至2015年5月收治入院的AMI患者85例,以1.0μg·ml-1作为分界点,将所有患者分为D-二聚体升高组和D-二聚体正常组。对比两组患者的一般情况、血液流变学指标、超敏C-反应蛋白(hs-CRP)、B型钠尿肽(BNP)、左室射血分数(LVEF)及治疗后1个月内主要心脏不良事件(MACE)和出血发生率。分析D-二聚体和患者不良事件的相关性。结果:D-二聚体升高组的血沉、血浆黏度、全血黏度高切、全血黏度中切、全血黏度低切、红细胞压积、红细胞聚集指数、hs-CRP和BNP、治疗后1个月内MACE和出血发生率显著高于D-二聚体正常组,LVEF显著低于D-二聚体正常组(P<0.05)。D-二聚体和患者再次心肌梗死、再次血运重建、心脏死亡、少量出血和大量出血具有显著相关性(P<0.05)。结论:AMI患者血清D-二聚体水平对于其近期预后具有一定预测意义。
Objective: To analyze the value of D-dimer in predicting the risk of acute myocardial infarction (AMI) and prognosis. Methods: A total of 85 AMI patients admitted to our hospital from May 2012 to May 2015 were enrolled. All patients were divided into D-dimer-elevated group and D-dimer Normal body group. Blood rheology, high-sensitivity C-reactive protein (hs-CRP), B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) and within 1 month after treatment were compared between the two groups. Major adverse cardiac events (MACE) and bleeding rates. Analysis of D-dimer and patient-related adverse events. Results: Erythrocyte sedimentation rate, plasma viscosity, whole blood viscosity cut, whole blood viscosity cut, whole blood viscosity cut, hematocrit, erythrocyte aggregation index, hs-CRP and BNP in the elevated D-dimer group The incidence of MACE and hemorrhage in 1 month was significantly higher than that in normal D-dimer group and LVEF was significantly lower than that in normal D-dimer group (P <0.05). There was a significant correlation between D-dimer and repeat myocardial infarction, revascularization, cardiac death, minor bleeding, and extensive bleeding (P <0.05). Conclusion: The level of serum D-dimer in patients with AMI has some predictive value for its recent prognosis.