前言近年来,用数理统计方法已成功地将药物分子的各种理化性质与其生物活性建立了定量联系。然而这种方法不能得出先导化合物,亦即不能获得某种特定生物活性所必需的分子结构,对于真正的药物设计来讲,这是不全面的。为弥补这一点,最近各研究所正在根据“药物一受体理论”探索药物设计。 Preface In recent years, using mathematical statistics has successfully established a quantitative relationship between various physical and chemical properties of drug molecules and their biological activity. However, this method does not yield the lead compound, ie, the inability to obtain the molecular structure necessary for a particular biological activity, which is incomplete for true drug design. To make up for this, more recently institutes are exploring drug design based on “drug-receptor theory.”