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目的:探讨MMP-9、Survivin、COX-2及Ki67在人胃癌组织中的表达及临床意义。方法:采用免疫组化S-P法,检测58例患者胃癌组织和正常胃黏膜组织中MMP-9、Survivin、COX-2及Ki67的表达情况。结果:MMP-9、Survivin和COX-2在胃癌组织中的阳性表达率均显著高于正常胃黏膜组织(P<0.01);MMP-9、Survivin和COX-2的阳性表达率与患者的性别、年龄及癌灶的部位和大小无关(P>0.05),而与胃癌的浸润深度、淋巴结转移及TNM分期有关(P<0.05),MMP-9的阳性表达率又与胃癌分化程度有关(P<0.05);而且三者之间均有相关性(P<0.05)。在胃癌组织中MMP-9、Survivin、COX-2表达阳性组与阴性组比较,Ki67LI表达有显著性差异(P均<0.01)。结论:MMP-9、Survivin、COX-2及Ki67在胃癌的发生、发展中起着重要作用,可做为判断胃癌生物学行为和预后的重要指标。
Objective: To investigate the expression and clinical significance of MMP-9, Survivin, COX-2 and Ki67 in human gastric cancer. Methods: The expressions of MMP-9, Survivin, COX-2 and Ki67 in 58 gastric cancer tissues and normal gastric mucosa tissues were detected by immunohistochemical S-P method. Results: The positive rates of MMP-9, Survivin and COX-2 in gastric cancer tissues were significantly higher than those in normal gastric mucosa tissues (P <0.01). The positive rates of MMP-9, Survivin and COX- (P> 0.05), but not with the location and size of the tumor (P> 0.05), but with the depth of invasion, lymph node metastasis and TNM stage (P <0.05). The positive rate of MMP-9 was also related to the differentiation of gastric cancer <0.05), and there was a correlation between the three (P <0.05). The expression of Ki67LI in gastric cancer tissues was significantly higher than that in the negative group (P <0.01). Conclusion: The expressions of MMP-9, Survivin, COX-2 and Ki67 play an important role in the occurrence and development of gastric cancer, which may be used as an important index to judge the biological behavior and prognosis of gastric cancer.