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目的 探讨CD44粘附分子表达与肿瘤转移相关性的意义.方法 采用LSAB免疫组化法对淋巴结转移性腺癌31例,鳞癌27例,和伴有淋巴结转移的鼻咽癌20例,食管鳞癌39例的原发癌石蜡切片进行CD44单抗染色,观察其表达阳性率及反应强度.结果1.淋巴结转移性腺癌CD44阳性表达18例(57%),转移性鳞癌阳性表达7例(2%),两组间腺癌阳性表达率明显高于鳞癌(P0.05).2.伴有淋巴结转移的鼻咽癌阳性表达11例,占55%(11/20),食管鳞癌阳性表达25例,(64%).两组间阳性表达率无明显差异(P>0.05),且阳性反应强度亦无显著的差异(P>0.05).结论 在多数肿瘤CD44表达与肿瘤转移密切相关,而以CD44V为明显,但无一致性.因此CD44不能作为肿瘤转移通用性标记物.
Objective To investigate the correlation between the expression of CD44 adhesion molecules and tumor metastasis. Methods LSAB immunohistochemistry was used for 31 cases of lymph node metastatic adenocarcinoma, 27 cases of squamous cell carcinoma, 20 cases of nasopharyngeal carcinoma with lymph node metastasis, and esophageal squamous cell carcinoma. 39 cases of primary cancer paraffin sections were stained by CD44 monoclonal antibody, and the positive rate and response intensity were observed. Results 1. The positive expression of CD44 in lymph node metastatic adenocarcinoma was 18 cases (57%), and the positive expression of metastatic squamous carcinoma was 7 cases (2 cases). %)) The positive rate of adenocarcinoma between the two groups was significantly higher than that of squamous cell carcinoma (P < 0.05). However, hilar lymph node metastasis was higher in squamous cell carcinoma of the lung than in adenocarcinoma. There was no significant difference in the positive expression intensity between the two groups (P> 0.05). The positive expression of nasopharyngeal carcinoma with lymph node metastasis was 11 cases, accounting for 55% (11/20). The positive expression of esophageal squamous cell carcinoma was 25 cases (64%). There was no significant difference in the positive expression rate between the two groups ( P>0.05), and there was no significant difference in positive reaction intensity (P>0.05). Conclusions CD44 expression in most tumors is closely related to tumor metastasis, but CD44V is obvious, but there is no consistency. Therefore, CD44 cannot be used as tumor metastasis Sex markers.