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有报告产前暴露于抗惊剂或患癫痫母亲增加了先天性畸形的危险性。本文目的是研究癫痫母亲的后代先天畸形的发生率,并寻找可能的危险因素。作者对305例癫痫妇女的318次妊娠进行了前瞻性研究。207例妊娠期使用单药治疗,82例、19例、和1例分别用2、3、4种抗癫痫药(AED_s),9例未用AEDs,仅当抽搐频繁增加时才更改药物。母妊期至少每4周由产科及神经科医师检查一次,并做血浆AEDs 浓度监测及常规实验室检查。本文报告妊娠期、胎儿、新生儿出生时及第10日龄时发现的畸形及轻度异常(minor anomalies)。
Prenatal exposure to anticonvulsants or epilepsy mothers has been reported to increase the risk of congenital malformations. The purpose of this article is to study the incidence of congenital malformations in offspring of epileptic mothers and to search for possible risk factors. The authors prospectively studied 318 pregnancies in 305 epileptic women. Of the 207 pregnancies treated with monotherapy, 82, 19, and 1 with 2, 3, 4 antiepileptic drugs (AEDs) and 9 with no AEDs, medications were changed only when seizures increased frequently. Mother’s pregnancy at least every 4 weeks by the obstetric and neurological examination, and do plasma AEDs concentration monitoring and routine laboratory tests. This article reports abnormalities and minor anomalies found during pregnancy, fetuses, newborns at birth and at 10 days of age.