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以５０３株葡萄球菌（金葡球菌４０１株，表葡球菌１０２株）为研究对象，通过琼脂稀释法测定万古霉素等１１种抗菌药物的最低抑菌浓度，评价其体外抗菌活性，同时对耐药性进行了分析。结果显示：万古霉素、去甲万古霉素和替考拉宁对葡萄球菌的ＭＩＣ９０值分别为１、２、２ｍｇ／Ｌ，氧氟沙星及利福平分别为８、３２ｍｇ／Ｌ，苯唑西林、庆大霉素、磷霉素及磺胺药物为１２８ｍｇ／Ｌ，红霉素为２５６ｍｇ／Ｌ。５０３株葡萄球菌中，１３６株金葡球菌（３３．９２％）及１０２株表葡球菌（２８．４３％）耐苯唑西林，１０种抗菌药物对这些耐药株的ＭＩＣ９０除万古霉素、去甲万古霉素和替考拉宁外，均明显增高。结果表明：万古霉素、去甲万古霉素和替考拉宁对葡萄球菌的体外抗菌活性最强，其次为氧氟沙星、利福平，红霉素、磺胺类及磷霉素最弱
The minimum inhibitory concentration of 11 antibacterial drugs such as vancomycin was determined by agar dilution method in 503 Staphylococcus aureus (Staphylococcus staphylococcus 401 and Staphylococcus epidermidis 102), and its antibacterial activity in vitro was evaluated. Medicinal properties were analyzed. The results showed that the MIC90 values of vancomycin, norvancomycin and teicoplanin against Staphylococcus aureus were 1, 2 and 2 mg / L respectively, ofloxacin and rifampicin were 8 and 32 mg / L, respectively Oxacillin, gentamicin, fosfomycin and sulfa drugs 128mg / L, erythromycin 256mg / L. Among the 503 staphylococci, 136 strains of Staphylococcus aureus (33.92%) and 102 strains of Staphylococcus epidermidis (28.43%) were resistant to oxacillin. MIC90 of these 10 strains of antibacterials against vancomycin, To vancomycin and teicoplanin, were significantly higher. The results showed that vancomycin, norvancomycin and teicoplanin had the strongest antibacterial activities on Staphylococcus aureus in vitro, followed by ofloxacin, rifampicin, erythromycin, sulfonamides and fosfomycin