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目的 分析转化生长因子 β1(TGF β1)在原发性肝癌 (PLC)诊断和判断预后方面的价值。 方法 以酶联免疫吸附试验法 (ELISA)测定肝癌、肝硬化 ,慢性肝炎、急性肝炎、继发性肝癌 (SHC)、消化道其它肿瘤和正常对照者的血浆TGF β1水平 ,并分析在PLC诊断方面的临床意义。结果 PLC组血浆TGF β1水平 ( 2 2 1± 1 19μg/L)均显著高于 (P <0 0 5 )正常对照组 ( 0 67± 0 11μg/L)、肝硬化 ( 0 95± 0 2 3 μg/L)、慢性肝炎 ( 0 98± 0 2 0 μg/L)、急性肝炎 ( 0 72± 0 3 7μg/L)、SHC( 0 89± 0 19μg/L)和消化道其它肿瘤 ( 0 82±0 0 9μg/L)。如以血浆TGF β1水平 1 2 μg/L为界 ,其诊断PLC的灵敏性和特异性分别为 89 5 %和 94 0 %。并且与血清AFP浓度、肿块大小均无相关性 ,与AFP联合检测可提高PLC诊断阳性率。结论 资料提示TGF β1过度表达与肝癌形成有关 ,血浆TGF β1分析有助于肝癌的诊断和转移监测
Objective To analyze the value of transforming growth factor β1 (TGF β1) in the diagnosis and prognosis of primary liver cancer (PLC). Methods The level of plasma TGF-β1 in hepatocellular carcinoma, cirrhosis, chronic hepatitis, acute hepatitis, secondary hepatocellular carcinoma (SHC), other gastrointestinal tract tumors and normal controls was measured by enzyme-linked immunosorbent assay (ELISA) The clinical significance. Results The level of plasma TGF-β1 in PLC group was significantly higher than that in control group (0 67 ± 0 11 μg / L) and cirrhosis (0 95 ± 0 2 3 2 2 1 ± 1 19 μg / L, P 0 05) chronic hepatitis (0 98 ± 0 2 0 μg / L), acute hepatitis (0 72 ± 0 37 microg / L), SHC (0 89 ± 0 19 microg / L) and other digestive tract tumors ± 0 0 9 μg / L). For example, the sensitivity and specificity of diagnosing PLC were 89 5% and 94 0%, respectively, at the level of plasma TGF β1 of 12 μg / L. And no correlation with serum AFP concentration, tumor size, combined with AFP detection can increase the positive rate of PLC diagnosis. Conclusion The data suggest that TGF β1 overexpression is associated with the formation of hepatocellular carcinoma. The analysis of plasma TGF β1 is helpful for the diagnosis and metastasis of hepatocellular carcinoma