烷基芳基醚结构广泛存在于天然和人工药物中,Pd催化的脂肪醇的芳基化反应是合成这类化合物的重要方法之一.重点综述了成功运用于脂肪醇的C—O偶联反应的四大类配体,对C—O偶联反应的应用进行了概述,对该类反应研究前景也进行了展望. Alkyl aryl ether structures are widely found in natural and artificial drugs. Pd-catalyzed arylation of fatty alcohols is one of the most important methods for the synthesis of these compounds. C-O couplings successfully applied to fatty alcohols are reviewed Reaction of the four major types of ligands, the application of C-O coupling reactions are summarized, the prospects for such reactions are also prospected.