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本文用免疫组织化学和肝组织病理学方法对98例病毒性肝炎患者的 HBV血清学标志与肝组织内 HBAg 分布的关系进行了探讨。血清中 HBsAg、抗—HBc、HBeAg 和 DNA—P 不论一项阳性或四项均阳性,肝组织内 HBAg 检出率均高。但四项指标均阴性的13例中,肝组织内 HBAg 检出率为59.8%(7/13)。抗—HBe 阳性的9例中肝组织内 HBAg 的检出率为77.85(7/9),抗—HBs 阳性的10例中,检出率为30%(3/10)。表明 HBV 血清标志与肝组织内 HBAg 的出现和消失并不同步。
In this paper, the relationship between HBV serological markers and HBAg distribution in liver tissue of 98 patients with viral hepatitis was studied by immunohistochemistry and liver histopathology. Serum HBsAg, anti-HBc, HBeAg and DNA-P regardless of a positive or four were positive, the detection rate of HBAg in liver tissue were high. However, among the 13 patients who were negative in all four indexes, the detection rate of HBAg in liver tissue was 59.8% (7/13). The positive rate of HBAg in hepatic tissue was 77.85 (7/9) in 9 anti-HBe positive and 30% (3/10) in 10 anti-HBs positive. That HBV serum markers and the occurrence and disappearance of HBAg in liver tissue are not synchronized.