目的了解肝硬变患者血浆一氧化氮（ＮＯ）含量及血清促卵泡素（ＦＳＨ）、促黄体素（ＬＨ）、泌乳素（ＰＲＬ）、雌二醇（Ｅ２）、睾酮（Ｔ）浓度，并探讨ＮＯ与性激素水平改变及某些临床表现的关系．方法肝硬变组５０例，全部为男肝炎后肝硬变患者，平均年龄５９岁±２６岁．其中１３例经Ｂ型超声证实无腹水，３７例有少量以上腹水．对照组３０例，为男性健康志愿者和献血员，平均年龄５２岁±１１岁．经方差分析肝硬变组和对照组年龄无显著差异（Ｐ＞００５）．我们研究采用高压液相色谱法测定ＮＯ血浆代谢产物亚硝酸根（ＮＯ－２）和硝酸根（ＮＯ－３）浓度，间接反应体内ＮＯ水平；采用放射免疫分析法测定血中ＦＳＨ，ＬＨ，ＰＲＬ，Ｅ２，Ｔ浓度．结果肝硬变患者血浆ＮＯ水平（ｎｇ／Ｌ）极显著高于对照组（３４８９±６７１ｖｓ２４３０±４７９，Ｐ＜００１），血清ＰＲＬ（μｇ／Ｌ），Ｅ２（ｎｇ／Ｌ）显著高于对照组（４０±２０ｖｓ２０±７，Ｐ＜００１；７０±２１ｖｓ４７±１３，Ｐ＜００１），Ｔ水平（ｎｇ／Ｌ）显著低于对照组（３５４±１０３ｖｓ５８８±８６，Ｐ＜００１），ＦＳＨ，ＬＨ两组差异无显著性．血浆ＮＯ水平与清蛋白（Ａ）呈负相关（ｒ＝－０６１，Ｐ＜０? Objective To investigate the levels of plasma nitric oxide (NO) and the levels of serum FSH, PRL, E2 and T in patients with cirrhosis, And sex hormone levels and some changes in clinical manifestations. Methods 50 patients with cirrhosis, all patients with posthepatitic cirrhosis, mean age 59 ± 26 years old. Among them, 13 cases were confirmed as non-ascites by B-mode ultrasound and 37 cases as few as ascites. Control group of 30 cases, male healthy volunteers and blood donors, with an average age of 52 years ± 11 years. There was no significant difference in age between cirrhosis group and control group by analysis of variance (P> 005). We studied the use of high pressure liquid chromatography determination of NO plasma nitric oxide (NO-2) and nitrate (NO-3) concentrations, indirect reaction of NO levels in vivo; radioimmunoassay method for the determination of blood FSH, LH, PRL , E2, T concentration. Results The level of plasma NO (ng / L) in patients with cirrhosis was significantly higher than that in controls (3489 ± 671 vs 2430 ± 479, P <001), and serum PRL (μg / L) and E2 The levels of ng / L in the control group (40 ± 20 vs. 20 ± 7, P <001; 70 ± 21 vs 47 ± 13, P <001) were significantly lower than those in the control group (354 ± 103 vs 588 ± 86, P <0  01), FSH, LH no significant difference between the two groups. Plasma NO levels were negatively correlated with albumin (A) (r = -0.61, P <