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目的探讨血清细胞因子与引起慢性非细菌性前列腺炎(CAP)病原体的关系。方法用ELISA法对112例CAP患者(其中CAPⅠ组80例,CAPⅡ组32例)血清进行IL-2、IL-4、IL-8、TNF-α检测, PCR法检查衣原体、支原体、病毒(HPV、HSV),同时,以20例健康男性作正常对照,并对所取得的数据进行统计学分析。结果(1)CAPⅠ组血清中的IL-2、IL-4、IL-8、TNF-α均有不同程度的升高,与CAPⅡ组和正常对照组相比差异显著(P<0．01或P<0．05),CAPⅡ组血清中IL-2、IL-4、TNF-α与正常对照组比较无显著性差异(P>0．05);(2)衣原体、支原体感染患者血清中的IL-2、IL-4、IL-8、TNF-α与对照组相比差异显著(P<0．01或P<0．05),痫毒感染患者血清中的IL-2、TNF-α与对照组比较有显著性差异(P<0．01或P<0．05),未检出病原体患者血清中的IL-2、IL-4、TNF-α与对照组比较差异无显著性(P>0．05)。结论血清IL-2、IL-4、IL-8、TNF-α水平与CAP病原体间有一定的相关性,它们在CAP发生发展过程中可能起着重要作用,对CAP辅助性诊断有较大应用价值。
Objective To investigate the relationship between serum cytokines and pathogens causing chronic nonbacterial prostatitis (CAP). Methods Serum IL-2, IL-4, IL-8 and TNF-α in 112 patients with CAP (including 80 cases in CAPⅠgroup and 32 cases in CAPⅡ group) were detected by ELISA. The levels of IL-2, IL- , HSV). At the same time, 20 healthy males were used as normal controls, and the data were statistically analyzed. Results (1) The serum levels of IL-2, IL-4, IL-8 and TNF-α in CAPⅠgroup all increased to some extent, which were significantly different from those in CAPⅡgroup and normal control group P <0.05). There was no significant difference between the serum levels of IL-2, IL-4 and TNF-αin CAPII group and normal control group (P> 0.05). (2) Serum The levels of IL-2, IL-4, IL-8 and TNF-α in serum of patients with epilepsy were significantly higher than that of the control group (P <0.01 or P <0.05) (P <0.01 or P <0.05). The levels of IL-2, IL-4 and TNF-α in sera of patients without pathogens were not significantly different from those in control group P> 0.05). Conclusions Serum levels of IL-2, IL-4, IL-8 and TNF-α have some correlation with the pathogens of CAP. They may play an important role in the development of CAP and have a great application in the diagnosis of CAP value.