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目的比较奥沙利铂(L-OHP)联合不同使用方法5-氟尿嘧啶,亚叶酸钙(5-Fu/FA)方案治疗晚期结肠直肠癌的疗效及不良反应。方法62例患者均可参加疗效评价,ArmA方案32例,ArmB方案30例,AnnA方案：L-OHP 130mg/m~2静滴d1；FA200mg/m~2/d,5-Fu 425mg/m~2/d分别静滴,均d1-5,每3周重复,3周为1周期。ArmB方案：L-OHP 85mg/m~2静滴d1；FA200mg/m~2/d静滴后,5-Fu400 mg/m~2/d静推,然后5- Fu600mg/m~2/d持续微量泵注射22小时,d1-2,每2周重复,4周为1周期。结果ArmA方案CR1例,PR14例,总有效率46．9％。ArmB方案CR1例,PR11例,总有效率40％。均较少严重不良反应。结论L-OHP联合不同使用方法5-Fu/FA方案治疗晚期结肠直肠癌均有较高疗效,毒副作用相近。
Objective To compare the efficacy and side effects of oxaliplatin (L-OHP) combined with 5-fluorouracil and leucovorin (5-Fu / FA) in the treatment of advanced colorectal cancer. Methods Sixty-two patients were enrolled in this study. 32 cases were treated with ArmA regimen and 30 cases were treated with ArmB regimen. AnnA regimen: L-OHP 130 mg / m 2 intravenous drip d1; FA200mg / m 2 / d; 2 / d were intravenous infusion, were d1-5, repeated every 3 weeks, 3 weeks for a cycle. ArmB regimen: L-OHP 85mg / m ~ 2 intravenous d1; FA200mg / m ~ 2 / d intravenous drip, 5-Fu 400mg / m ~ 2 / d static push, then 5- Fu600mg / m ~ 2 / d sustained Micro-pump injection 22 hours, d1-2, repeated every 2 weeks, 4 weeks for a cycle. Results ArmA CR1 cases, PR14 cases, the total efficiency of 46.9%. ArmB CR1 cases, PR11 cases, the total efficiency of 40%. Less serious serious adverse reactions. Conclusions L-OHP combined with 5-Fu / FA regimens with different methods of treatment for advanced colorectal cancer have higher efficacy and similar side effects.