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本文观察了抗乙肝免疫核糖核酸注射液治疗慢性乙型肝炎的临床疗效。主要对临床表现、肝功及血清乙肝标志等进行观察。治疗组４８例，设对照组５０例。抗乙肝免疫核糖核酸注射液２ｍｇ，隔日肌注，第二个月每周２次，第三个月每周１次，疗程３个月。对照组不给予任何免疫调节剂。治疗组中治疗前血清谷丙转氨酶（ＡＬＴ）升高者，至疗程结束时８００％降至正常（Ｐ＜００１），ＨＢｓＡｇ阴转率３３３％（Ｐ＜００５），ＨＢｅＡｇ阴转率７１４％（Ｐ＜００１），ＨＢＶ－ＤＮＡ阴转率５３７％（Ｐ＜００５），其差异有显著性。表明抗乙肝免疫核糖核酸注射液是治疗慢性乙型肝炎的较满意的药物。治疗组未见毒副反应。
This article observed the anti-hepatitis B immune RNase injection in the treatment of chronic hepatitis B clinical curative effect. The main clinical manifestations, liver function and serum hepatitis B markers were observed. The treatment group 48 cases, control group 50 cases. Anti-hepatitis B immune RNA injection 2mg, intramuscular injection every other day, the second month 2 times a week, the third month once a week, the course of 3 months. The control group did not receive any immunomodulatory agent. In the treatment group, the serum ALT levels before treatment were reduced to 800% (P0.01), HBsAg negative conversion rate was 333% (P0.05) , The negative conversion rate of HBeAg was 714% (P <001), and the negative conversion rate of HBV-DNA was 537% (P <005). The difference was significant. It is indicated that anti-hepatitis B immune RNA injection is a satisfactory drug for the treatment of chronic hepatitis B. The treatment group did not see toxic side effects.