目的评价环丙氟哌酸（ＣＰＦＸ）对多耐药肺结核（ＭＤＲＰＴＢ）的近远期疗效。方法５１例ＭＤＲＰＴＢ患者分为两组：２６例应用６ＣＨＥＴＨＴ／６ＣＨＴＨＴ方案治疗，２５例采用６ＨＥＴＨＴ／６ＨＴＨＴ方案治疗。结果疗程结束时，治疗组痰菌阴转率（７６９％）明显高于对照组（２８０％）（Ｐ＜００１）；经三年随访，治疗组和对照组细菌学复发率分别为１００％和５７１％，两组间差异有显著性（Ｐ＜００５）。结论ＣＰＥＸ是治疗ＭＤＲＰＴＢ的较为有效的药物。 Objective To evaluate the short-term and long-term effects of ciprofloxacin (CPFX) on multidrug resistant tuberculosis (MDR-PTB). Methods 51 patients with MDRPTB were divided into two groups: 26 patients treated with 6CHETHT / 6CHTHT regimen and 25 patients treated with 6HETHT / 6HTHT regimen. Results At the end of the course of treatment, the sputum negative conversion rate (769%) in the treatment group was significantly higher than that in the control group (280%) (P0.01). After three years’ follow-up, the bacteriological recurrences in the treatment group and the control group Rates were 10  0% and 57  1%, the difference between the two groups was significant (P <0  05). Conclusion CPEX is a more effective drug for the treatment of MDR-PTB.