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The mode of action of drugs used to treat depression has long remained mysterious.A new study now shows that unexpect-edly,this diverse group of chemicals binds to a well-studied growth factor receptor in the brain.rnDepression negatively impacts the everyday lives of very large numbers of people worldwide.Alongside with psychotherapy and related approaches,drugs are also extensively used to improve the well-being of patients suffering from depression.These drugs typically target major neurotransmitter systems in the brain,including those using monoamines such as serotonin in parti-cular.1