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采用免疫组织化学ＬＳＡＢ法对９０例垂体瘤增殖细胞核抗原（ＰＣＮＡ）进行检测，发现ＰＣ－ＮＡ指数随肿瘤体积的增大而增高，复发组垂体瘤ＰＣＮＡ增殖指数明显高于非复发组（Ｐ＜０．０１），且同一病人复发肿瘤较初发肿瘤的ＰＣＮＡ指数明显增高（Ｐ＜０．０５）。结果表明ＰＣＮＡ指数可作为垂体腺瘤侵袭性及预后的指标之一。
The immunohistochemistry LSAB method was used to detect the proliferation of PCNA in 90 cases of pituitary tumors. It was found that the PC-NA index increased with the increase of the tumor volume, and the PCNA proliferation index of pituitary tumors in the relapse group was significantly higher than that in the non-recurrence group (P< 0.01), and the PCNA index of the recurring tumor in the same patient was significantly higher than that of the initial tumor (P<0.05). The results showed that PCNA index can be used as one of the indicators of pituitary adenoma invasion and prognosis.