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在所有已知的生长因子中,血小板生长因子(PDGF)是诱发间质细胞增生的最主要物质.作者回顾了有关肺细胞产生PDGF 的资料,同时探讨PDGF 在肺间质纤维化(IPF)发病机理中的作用.人PDGF 是分子量约30000的二聚阳离子糖蛋白,其局部分泌和活性是研究间质性肺疾病的主要课题。目前已知,PDGF 可由内皮细胞、平滑肌细胞、成纤维细胞及巨噬细胞产生.近来,作者实验室以及其它一些实验室把研究重点放在肺巨噬细胞源性(MD)-PDGF 及其控制成纤维细胞增生的机制上.
Among all known growth factors, platelet-derived growth factor (PDGF) is the most important substance that induces proliferation of stromal cells. The authors reviewed data on the production of PDGF in lung cells and explored the role of PDGF in the pathogenesis of pulmonary fibrosis (IPF) Mechanism PDGF is a dimeric cationic glycoprotein with a molecular weight of about 30,000. Local secretion and activity of PDGF are the major topics in the study of interstitial lung disease. It is now known that PDGF can be produced by endothelial cells, smooth muscle cells, fibroblasts and macrophages.Recently, the author laboratory and other laboratories have focused their research on the regulation of pulmonary macrophage-derived (MD) -PDGF and its control Mechanism of fibroblast proliferation.