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目的 探讨P53 及c -myc蛋白在食管癌及癌前病变中的表达及意义。方法 应用免疫组化SP法检测P53 及c -myc在 6 0例食管癌及 33例非典型增生中的表达。 结果 P53 及c -myc蛋白分别在食管癌与非典型增生I～II级中表达有显著差异 (P <0 .0 5 ) ;在食管癌与非典型增生III级表达中无显著差异 (P >0 .0 5 )。结论 P53 及c -myc蛋白异常表达 ,可为食管癌和癌前病变界限的划分提供参考依据。
Objective To investigate the expression and significance of P53 and c-myc protein in esophageal cancer and precancerous lesions. Methods Immunohistochemical SP method was used to detect the expression of P53 and c-myc in 60 cases of esophageal cancer and 33 cases of atypical hyperplasia. Results The expressions of P53 and c-myc protein were significantly different between esophageal cancer and atypical hyperplasia in grades I-II (P < 0.05). There was no significant difference in grade III expression of esophageal carcinoma and atypical hyperplasia (P > 0.05). 0 .0 5 ). Conclusion The abnormal expression of P53 and c-myc protein can provide reference for the division of the boundaries of esophageal cancer and precancerous lesions.