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目的探究病毒性脑炎患儿血清神经元特异性烯醇化酶检测的临床意义。方法 21例病毒性脑炎患儿设为观察组,同期上呼吸道感染合并热性惊厥19例患儿设为对照组。对两组患儿进行检查,提取患儿脑脊液和血样本,分别检测和记录两组患儿的脑脊液和血清神经元特异性烯醇化酶指标水平。结果观察组患儿的脑脊液神经元特异性烯醇化酶水平为(22.15±5.68)μg/L,血清中的水平为(17.79±4.26)μg/L;对照组脑脊液神经元特异性烯醇化酶水平为(8.89±1.12)μg/L,其血清水平为(7.76±0.89)μg/L。两组比较差异均具有统计学意义(P<0.05)。结论在病毒性脑炎患儿急性期的脑脊液和血清神经元特异性烯醇化酶显著升高,可作为评价病毒性脑炎脑组织损伤客观指标之一。
Objective To investigate the clinical significance of serum neuron specific enolase in children with viral encephalitis. Methods Twenty-one children with viral encephalitis were enrolled in the observation group. 19 children with upper respiratory tract infection complicated with febrile seizures were enrolled as control group. The two groups of children were examined, cerebrospinal fluid and blood samples were collected from children, and cerebrospinal fluid and serum neuron-specific enolase levels were detected and recorded in both groups. Results The level of neuron-specific enolase in cerebrospinal fluid of the observation group was (22.15 ± 5.68) μg / L and the level of serum in the observation group was (17.79 ± 4.26) μg / L. The neuron-specific enolase level (8.89 ± 1.12) μg / L and the serum level was (7.76 ± 0.89) μg / L. The differences between the two groups were statistically significant (P <0.05). Conclusion Cerebrospinal fluid and serum neuron specific enolase are significantly increased in children with viral encephalitis at the acute stage, which may be used as an objective index to evaluate brain damage in viral encephalitis.