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用比色法测定大鼠尿和组织的羟脯氨酸含量。发现羟脯氨酸在24小时尿中排泄量,肾血管狭窄型高血压大鼠明显高于正常对照组(P<0.05);自发性高血压大鼠与正常组无显著性差异(P>0.05)。心肌羟脯氨酸含量,肾血管型比正常对照组高(P<0.05);自发性高血压大鼠低于正常对照组(P<0.05),主动脉中羟脯氨酸的含量,肾血管性高血压组和正常组之间无显著性差异(P>0.05);自发性高血压组比正常组明显低(P<0.01),肾血管性高血压大鼠中,狭窄肾动脉中羟脯氨酸含量高于对侧(P<0.05)。
The hydroxyproline content of rat urine and tissue was determined by colorimetry. The urinary excretion of hydroxyproline was found in 24-hour urine, and the renal vascular stenosis-induced hypertension was significantly higher than that in the normal control group (P<0.05); there was no significant difference between the spontaneous hypertension group and the normal group (P>0.05). ). Myocardial hydroxyproline content and renal vascularity were higher than those in the normal control group (P<0.05); Spontaneously hypertensive rats were lower than the normal control group (P<0.05); hydroxyproline content in the aorta, renal blood vessels There was no significant difference between the hypertensive group and the normal group (P>0.05); the spontaneous hypertension group was significantly lower than the normal group (P<0.01). In the renal hypertensive rat, serotonergic vasospasm in the stenotic renal artery The content of amino acids was higher than that of the contralateral side (P<0.05).