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目的观察和分析急性心肌梗死(AMI)患者PCI术后非梗死区冠脉血流储备(CFR)的变化及其对左室功能的影响。方法 22名AMI患者PCI术后1周行二维超声心动图和多巴酚丁胺负荷实时心肌声学造影(MCE)检查,测量左室功能和梗死区、非梗死区CFR,比较非梗死区CFR与梗死区及正常对照组CFR;根据非梗死区CFR值将患者分为两组,比较两组远期左室功能的变化。结果非梗死区CFR值与正常对照组相比明显下降,非梗死区CFR与左室舒张末期容积呈负相关。结论 AMI后非梗死区心肌同样存在微循环功能障碍,非梗死区CFR值能预测AMI后远期左室功能。
Objective To observe and analyze the changes of non-infarction coronary flow reserve (CFR) and its effect on left ventricular function in patients with acute myocardial infarction (AMI). Methods Twenty-two AMI patients underwent PCI and dobutamine stress real-time myocardial contrast echocardiography (MCE) one week after PCI to measure left ventricular function and CFR in infarction and non-infarction areas. CFR And CFR of infarction area and normal control group. The patients were divided into two groups according to non-infarction CFR value, and the changes of long-term left ventricular function were compared between the two groups. Results The CFR of non-infarcted area was significantly lower than that of the normal control group. CFR of non-infarcted area was negatively correlated with left ventricular end-diastolic volume. Conclusions There is also microcirculation dysfunction in non-infarcted myocardium after AMI. CFR in non-infarct area can predict long-term left ventricular function after AMI.