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目的:综述有关血管内皮细胞生长因子(vascularendothelialgrowthfac-tor,VEGF)的实验结果及其对成骨的影响,明确VEGF是否能促进骨的形成。资料来源:资料来源于http://www.ncbi.nlm.nih.gov/pubmed和http://www.zglckf.com数据库等相关网站,采取电子数据检索方式获得。资料选择:选择有关VEGF的文章以及VEGF影响成骨的文章近30篇。不考虑文章中是否应用随机设计、盲法。数据提炼:这些研究证实了VEGF和VEGF受体的结构、生物学特性、表达。提示VEGF通过促进新生血管的形成、加快骨转换和阻止软骨细胞凋亡在软骨内成骨中扮演重要角色。膜内成骨中,在无软骨出现的情况下,成骨细胞产生、应答VEGF。VEGF激活、趋化破骨细胞,同时趋化、分化成骨细胞和促进基质的矿化。目前关于局部单纯应用外源性VEGF能否促进成骨仍有争论。但在某些情况如局部缺血环境下,增加局部VEGF可促进成骨。资料综合:与对照组相比,VEGF能通过对软骨内成骨、膜内成骨的影响促进骨的发生、形成和改建。结论:局部VEGF治疗的优势在于其既可刺激血管形成又可促进骨的形成和改建。如果最终能应用VEGF的这些特性治疗缺血性骨坏死、骨缺损、骨不连等疾病,将发现一条新的治疗途径。
OBJECTIVE: To summarize the experimental results of vascular endothelial growth factor (VEGF) and its effect on osteogenesis, and to clarify whether VEGF can promote the formation of bone. Source: The data are obtained from electronic databases such as http://www.ncbi.nlm.nih.gov/pubmed and http://www.zglckf.com databases. Data selection: Select articles about VEGF and VEGF nearly 30 articles that affect osteogenesis. Regardless of whether the article applies random design, blind method. Data Refinement: These studies confirm the structure, biological properties, and expression of VEGF and VEGF receptors. These results suggest that VEGF plays an important role in endochondral ossification by promoting angiogenesis, accelerating bone turnover and preventing chondrocyte apoptosis. In intramedullary osteoblasts, osteoblasts develop and respond to VEGF in the absence of cartilage. VEGF is activated, chemotactic to osteoclasts while chemotaxis, differentiating into osteoblasts and promoting mineralization of the matrix. At present, there is still debate about whether local application of exogenous VEGF can promote osteogenesis. However, in some cases, such as ischemic environment, increased local VEGF can promote osteogenesis. DATA SYNTHESIS: Compared with the control group, VEGF can promote bone formation, formation and remodeling through the effect on intraosseous and intramedullary osteogenesis. CONCLUSIONS: The advantage of local VEGF therapy is that it both stimulates blood vessel formation and promotes bone formation and remodeling. If we can finally apply these features of VEGF in the treatment of ischemic osteonecrosis, bone defects, nonunion and other diseases, will find a new therapeutic approach.