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目的 观察碳酸锂与CEP方案联合应用的疗效及对患者遗传损伤的抑制作用。方法101例实体瘤患者随机分为两组,治疗组(CEP方案+Li2CO3+基础用药)53例,对照组(CEP方案+基础用药)48例。疗程6周。结果 治疗组有效率为62.3％,对照组有效率为37.5％(P<0.05)。治疗组患者血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和骨髓细胞核微粒(MNF)治疗前后比较差异有非常显著性(P<0.01);外周血白细胞治疗前后比较差异有显著性(P<0.05)。结论 碳酸锂能提高化疗药物CEP方案的疗效,并能减轻化疗药物对人体的损伤作用。
Objective To observe the curative effect of lithium carbonate combined with CEP regimen and its inhibitory effect on patients’ genetic damage. Methods Totally 101 patients with solid tumors were randomly divided into two groups. The treatment group (CEP regimen + Li2CO3 + basic treatment) 53 cases, the control group (CEP regimen + basic medication) 48 cases. Treatment for 6 weeks. Results The effective rate was 62.3% in the treatment group and 37.5% in the control group (P <0.05). There were significant differences in the levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and bone marrow cells (MNF) in the treatment group before and after treatment (P <0.01) Before and after treatment, the difference was significant (P <0.05). Conclusion Lithium carbonate can improve the curative effect of CEP regimen of chemotherapy and reduce the damage of chemotherapy drugs on human body.