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目的：为保证抗菌药物安全有效，减少真菌感染的发生。方法：运用回顾性调查，对我院１９９７年下半年院内４５例因使用抗菌药物继发真菌感染的病例进行调查。结果：应用抗菌药物继发真菌感染是引起院内真菌感染的主要原因，且多发于年老、免疫力低下的患者，好发部位在肠道、泌尿道及口腔。且亚胺培南／西司他丁钠、第三代头孢菌素、喹诺酮等强效广谱抗菌药物是引起院内真菌感染的主要因素之一。结论：在抗菌药物使用过程中，要严格遵循抗菌药物的使用原则，酌情选用窄谱抗菌药物。同时应严密观察消化道、泌尿道、口腔等部位的真菌感染的指征，一旦诊断成立，应立即使用抗真菌药物。而在恶性血液病等特殊病例中，可适当考虑预防性使用抗真菌药物如氟康唑等。
Objective: To ensure the safe and effective antibacterial drugs to reduce the incidence of fungal infections. Methods: A retrospective survey was conducted to investigate 45 cases of secondary fungal infections caused by antibiotics in our hospital in the second half of 1997. Results: The secondary fungal infection with antibiotics was the main cause of nosocomial fungal infection. It was predominant in elderly and immunocompromised patients. The predilection sites were in the intestine, urinary tract and oral cavity. And imipenem / cilastatin sodium, the third-generation cephalosporins, quinolones and other potent broad-spectrum antibacterial drugs is one of the main factors causing fungal infections in the hospital. Conclusion: In the process of using antimicrobial drugs, we must strictly follow the use of antimicrobial drugs, use narrow spectrum antimicrobial drugs, as appropriate. At the same time should be closely observed digestive tract, urinary tract, oral and other parts of the fungal infection indications, once the diagnosis is established, the immediate use of antifungal drugs. In special cases such as hematologic malignancies, prophylactic use of antifungal drugs such as fluconazole may be considered as appropriate.