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多潘立酮(Domperidone,吗丁啉)为新型抗呕吐和胃动力药。目前,临床已广泛用于反流性胃炎、食道炎和多种原因引起的恶心、呕吐、上腹部饱胀等疾病的治疗。近年来,随着临床的广泛应用,其不良反应也渐增多。现简述如下,以供临床用药参考。1 引起乳汁分泌 因多潘立酮为多巴胺受体拮抗剂,催乳素的释放受垂体漏斗部的多巴胺所控制;这一部位在血脑屏障之外,多潘立酮可到达此部位,拮抗了“结节—漏斗”通路中的多巴胺受体,减少下丘脑释放催乳素抑制因子,因而使血清催乳素水平升高,导致乳汁分泌。
Domperidone (domperidone, domperidone) is a new anti-emetic and gastric motility drug. At present, the clinical has been widely used in the treatment of reflux gastritis, esophagitis and various causes of nausea, vomiting, upper abdominal fullness and other diseases. In recent years, with the wide application of clinical, its adverse reactions are also increasing. Are summarized below, for clinical reference. 1 causes milk secretion Domperidone is a dopamine receptor antagonist, release of prolactin by the pituitary funnel of dopamine control; this area outside the blood-brain barrier, domperidone can reach this site, antagonizing the “nodules - funnel” The dopamine receptors in the pathway, which reduce the release of prolactin from the hypothalamus, raise serum prolactin levels, leading to milk secretion.