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[目的]观察热毒宁和地塞米松注射液配伍稳定性。[方法]利用光阻法测定热毒宁与地塞米松注射液中的不溶性微粒,采用高效液相色谱法测定热毒宁与地塞米松注射液配伍放置几小时内栀子苷及绿原酸的含量变化,以及溶液外观和pH值变化,重点解决的关键技术问题是液相指纹图谱检测。[结果]配伍药液色泽、澄明度、pH值、主要成分含量、液相指纹图谱在配伍后4h内没有显著差异,不溶性微粒有显著差异。[结论]两种成分在配伍药液中含量相对稳定,但是不溶性微粒数远远超过标准,存在配伍禁忌。为保证临床用药安全,不建议配伍后使用。
[Objective] To observe the compatibility of detoxins and dexamethasone injection. [Method] The thermogravimetric method was used to determine the insoluble particles in injection of dexamethasone and injection of dexamethasone. The content of geniposide and chlorogenic acid Content changes, as well as the appearance of the solution and pH changes, the key technical problems to be resolved is liquid phase fingerprint detection. [Result] There was no significant difference in the color, clarity, pH value, main components and liquid fingerprints of compatibility liquid within 4 hours after compatibility, and the difference of insoluble particles was significant. [Conclusion] The content of the two components in the compatibility liquid was relatively stable, but the number of insoluble particles far exceeded the standard, there are compatibility taboo. To ensure the safety of clinical medication, it is not recommended to use after compatibility.