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目的:研究经脐静脉置管换血术治疗新生儿ABO和Rh血型不溶性黄疸的临床疗效,为新生儿溶血性黄疸的临床治疗提供指导。方法:对142例发生溶血性黄疸的新生儿行脐静脉置管换血术治疗,术中严密监测患儿血糖、血压、心率、呼吸等生命体征,术后严密监测患儿血常规、血生化指标,据治疗前后各项指标变化对换血治疗的疗效进行评价。结果:经换血治疗后血清总胆红素、间接胆红素、2微球蛋白、白细胞、血小板均呈现不同程度的下降,治疗前后数据比较差异具有统计学意义(P<0.05);血糖数值在治疗后出现上升,数值差异具有统计学意义(P<0.05);血红蛋白、血钙、血钠、血钾治疗前后数值差异不具有统计学意义(P>0.05)。结论:经脐静脉置管换血术治疗ABO和Rh血型不溶性黄疸后,患儿血清总胆红素、间接胆红素、白细胞、血小板等指标明显降低,能够有效治疗由溶血引起的高胆红素血症。
Objective: To study the clinical efficacy of transvascular umbilical vein catheterization in the treatment of neonatal ABO and Rh blood type insoluble jaundice and to provide guidance for the clinical treatment of neonatal hemolytic jaundice. Methods: 142 cases of neonatal hemolytic jaundice umbilical vein exchange transfusion, strict monitoring of blood glucose, blood pressure, heart rate, respiration and other vital signs in children during surgery, blood and blood biochemical indicators , According to the changes of various indicators before and after treatment to evaluate the efficacy of transfusion therapy. Results: The levels of serum total bilirubin, indirect bilirubin, 2 microglobulin, white blood cell and platelet all decreased to different extents after transfusions. The difference of the data before and after treatment was statistically significant (P <0.05) (P <0.05). The difference of hemoglobin, serum calcium, serum sodium and serum potassium before and after treatment did not reach statistical significance (P> 0.05). Conclusion: The transfusion of umbilical vein to treat ABO and Rh blood type insoluble jaundice, serum total bilirubin, indirect bilirubin, white blood cells, platelets and other indicators was significantly reduced, can effectively treat hemolysis caused by high bilirubin Blood disorders.