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胰岛素样生长因子结合蛋白-1(IGFBP-1)作为一种内分泌因子,在人类妊娠中发挥重要作用。在妊娠的不同时期,其含量和磷酸化程度均发生变化,与胚胎植入、胎儿生长发育、妊娠期高血压疾病、分娩启动等密切相关。从IGFBP-1表达的变化可了解各种妊娠期的生理病理现象,并用其诊断胎膜早破、预测早产。
Insulin-like growth factor binding protein-1 (IGFBP-1), as an endocrine factor, plays an important role in human pregnancy. In different stages of pregnancy, its content and degree of phosphorylation changes, and embryo implantation, fetal growth and development, pregnancy-induced hypertension disease, childbirth and so on are closely related. Changes in IGFBP-1 expression can be understood from a variety of physiological and pathological gestations, and use it to diagnose premature rupture of membranes to predict preterm birth.