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目的探讨复方生麻黄汤治疗非小细胞肺癌恶性胸腔积液的疗效。方法非小细胞肺癌伴恶性胸腔积液患者68例,随机分为采用复方生麻黄汤口服(治疗组)和单纯用顺铂腔内灌注化疗(对照组),每周1次,观察4周,详细记录近期疗效和用药后出现的毒副反应。结果治疗组近期有效率50.0%,对照组有效率31.2%,治疗组生活质量明显提高,治疗组的不良反应主要有心慌、出汗、兴奋等,对症处理后均可得到缓解。结论复方生麻黄汤治疗恶性胸腔积液疗效确切,不良反应少,值得临床进一步推广。
Objective To investigate the curative effect of compound Shengmahuang Decoction on malignant pleural effusion of non-small cell lung cancer. Methods Sixty-eight patients with non-small cell lung cancer and malignant pleural effusion were randomly divided into two groups: oral treatment with Fufang Shengmahuang Decoction (treated group) and chemotherapy with cisplatin alone (control group) once a week for 4 weeks, Detailed record of the recent efficacy and toxicity after treatment. Results In the treatment group, the effective rate was 50.0% in the recent period and that in the control group was 31.2%. The quality of life in the treatment group was significantly improved. The adverse reactions in the treatment group were mainly palpitation, sweating and excitement, and were relieved after symptomatic treatment. Conclusion Fufang Shengmahuang Decoction is effective in treating malignant pleural effusion and has few adverse reactions. It is worth further promotion in clinic.