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Objective:To explore the characteristic of operation,intra-operation treatment and the application of immunosuppressant in pediatric renal transplantation in order to improve therapeutic effectiveness.Methods:From March 1986 to October 2006,the clinical data of 63 children who underwent renal transplantation in our hospital were retrospectively analyzed.Results:The 1-,3-,5-,10-year graft survival rates were 98.4%,90.5%,88.9% and 68.3%, respectively.And the corresponding patient survival rates were 100%,95.2%,92.1%,71.4%.The body weight increased 4 to 12 kg and the body height grew up 2 to 6 cm during the first year post-transplantation.The main complications in the first year post-transplantation were hypertension(26/63,41.3%),crinosity(14/63,22.2%), drug-induced hepatic injury(11/63,17.5%),gingival hyperplasia(10/63,15.8%),pulmonary infection(9/63,14.3%), bone marrow suppression(5/63,7.9%),herpes(4/63,6.3%)and diabetes(3/63,4.8%).Conclusion:Renal transplantation is a preferred method for the treatment of children in end-stage renal disease(ESRD).Good tissue matching,proper operative time and pattern,peri-operactive care were essential to success,as well as appropriate immuno-suppressant strategy and good compliance.
Objective: To explore the characteristic of operation, intra-operation treatment and the application of immunosuppressant in pediatric renal transplantation in order to improve therapeutic effectiveness. Methods: From March 1986 to October 2006, the clinical data of 63 children who underwent renal transplantation in our The patients were retrospectively analyzed. Results: The 1-, 3-, 5-, 10-year graft survival rates were 98.4%, 90.5%, 88.9% and 68.3% respectively. And the corresponding patient survival rates were 100%, 95.2% , 92.1%, 71.4% .The body weight increased 4 to 12 kg and the body height grew up 2 to 6 cm during the first year post-transplantation.The main complications in the first year post-transplantation were hypertension (26/63, 41.3%), crinosity (14/63, 22.2%), drug-induced hepatic injury (11/63, 17.5%), gingival hyperplasia bone marrow suppression (5/63, 7.9%), herpes (4/63, 6.3%) and diabetes (3/63, 4.8%). Conclusion: Renal transplantation is a preferred method for the treatment of children in end-stage renal disease (ESRD) .Good tissue matching, proper operative time and pattern, peri-operactive care were essential to success, as well as appropriate immuno-suppressant strategy and good compliance.