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Both enantiomers of fluoxetine were synthesized in five steps from ethyl benzoylacetate(1)using microbial-chemical approach with overall yields of 59% and 62% respectively.(S)-Enan-tiomer can be obtained in >99% e.e.by resting cell of baker’s yeast and the R form was produced in 81 %e.e.by immobilized Geotrichum sp.G 38.