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一些研究指出利福平可能降低口服避孕药(OC)的有效性,故提出了同时使用其他药物对OC的有效性的影响问题。氨苄西林是一种广谱的半合成青霉素,1973年Mumford曾提出合并使用氨苄西林可能影响OC的有效性,此后,Dosseter报告了3名服OC同时使用氨苄西林的妇女发生了怀孕。为此,作者对11名有规则月经、年龄为21～39岁的妇女进行了研究。所有研究对象经一个基础周期(不服药)后,第二个周期开始服炔雌醇50μg+双醋炔诺醇1 mg,共21天,同时于周期第1～16天每天4次口服氨苄西林250mg或安慰剂。两组妇女均于基础周期的第十九天及服药周期的第十三、十九天取血用放射免疫法测定血清雌二醇
Some studies have pointed out that rifampicin may reduce the effectiveness of oral contraceptives (OC), it raised the simultaneous use of other drugs on the effectiveness of OC issue. Ampicillin is a broad-spectrum, semi-synthetic penicillin. Mumford’s proposal in 1973 that ampicillin was used in combination may have an effect on the efficacy of OC. Dosseter then reported on the pregnancies of three women taking OC ampicillin ampicillin. To this end, the author of 11 regular menstruation, aged 21 to 39 years of women were studied. All subjects after a basic cycle (not taking medication), the second cycle began ethinyl estradiol 50μg + 1 mg bicine acetylcarnate, a total of 21 days, at the same time on the 1st to 16th of the cycle 4 times daily oral ampicillin 250mg Or placebo. Both groups of women took blood on the nineteenth day of the basic cycle and on the thirteenth and nineteenth days of the medication cycle. Serum estradiol was measured by radioimmunoassay