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目的观察妊娠合并生殖道感染的干预治疗对胎膜早破(PROM)的预防作用。方法选择妊娠合并生殖道感染治疗组200例,妊娠合并生殖道感染未治疗组70例,妊娠无生殖道感染为正常对照组300例,观察三组胎膜早破发生率,观察绒毛膜羊膜炎发生率,并行免疫组织化学技术检测三组胎膜中基质金属蛋白酶-9(MMP-9)及金属蛋白酶组织抑制因子-1(TMP-1)的表达率。结果感染治疗组胎膜早破发生率低于感染未治疗组,高于正常对照组;感染未治疗组MMP-9 PU比值及MMP-9/TMP-1 PU比值高于治疗组和正常对照组;3组中TMP-1的PU值比较差异无统计学意义(P>0.05)。结论妊娠合并生殖道感染可提高胎膜中MMP-9表达率从而提高胎膜早破发生率,经过针对性治疗可有效减少胎膜早破及不良妊娠结局的发生。
Objective To observe the preventive effect of intervention treatment of pregnancy complicated with genital tract infection on premature rupture of membranes (PROM). Methods 200 cases of pregnancy complicated with genital tract infection were selected, 70 cases of pregnancy complicated with reproductive tract infection in untreated group, 300 cases of pregnancy-free reproductive tract infection as normal control group, observed the incidence of premature rupture of membranes in three groups, observed chorioamnionitis (MMP-9) and tissue inhibitor of metalloproteinase-1 (TMP-1) in three groups were detected by immunohistochemistry and immunohistochemistry. Results The incidence of premature rupture of membranes in infected patients was lower than that in untreated patients and higher than that in normal controls. The MMP-9 / PU ratio and the ratio of MMP-9 / TMP-1 PU in untreated patients were higher than those in untreated patients and normal controls There was no significant difference in PU value of TMP-1 in three groups (P> 0.05). Conclusion Pregnancy complicated with genital tract infection can increase the expression rate of MMP-9 in fetal membranes to improve the incidence of premature rupture of membranes. After targeted treatment, premature rupture of membranes and adverse pregnancy outcomes can be effectively reduced.