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目的探讨高血压患者左房到结构及功能变化与血浆心钠素水平的关系。方法应用超声心动图技术和放射性免疫测定法测定100例高血压患者的左房室结构及功能和血浆心钠素水平,并与50例年龄、性别配对的正常人比较。结果高血压左室肥厚组和非左室肥厚组血浆心钠素水平显著高于正常对照组(P<0.001),且左室肥厚组与非左室肥厚组之间亦有显著性差异;血浆心钠素水平与左房功能指标 LAV、LAT、LAP、LAF 及 MAP 呈高度线性意义,与 LAD、LVMI、LVEF、PFR、A峰、LVD、A/E 呈中度相关。结论随着高血压加重,血浆心钠素水平有增加趋势,测定血浆心钠素将有助于评价高血压左房室功能异常变化的程度。
Objective To investigate the relationship between left atrium structural and functional changes and plasma atrial natriuretic peptide in hypertensive patients. Methods Echocardiography and radioimmunoassay were used to determine left ventricular structure and function and plasma atrial natriuretic peptide levels in 100 hypertensive patients and compared with 50 age-matched and matched-sex normal subjects. Results Plasma atrial natriuretic peptide was significantly higher in hypertensive LV hypertensive group and non-LV hypertrophy group than in normal control group (P <0.001), and there was also a significant difference between LV hypertrophy group and non-LV hypertrophy group. Plasma The levels of atrial natriuretic peptide and left ventricular function index LAV, LAT, LAP, LAF and MAP were highly linear, and were moderately correlated with LAD, LVMI, LVEF, PFR, A peak, LVD and A / E. Conclusions With the increase of hypertension, plasma atrial natriuretic peptide level tends to increase. Determination of plasma atrial natriuretic peptide will be helpful to evaluate the degree of left ventricular dysfunction in hypertension.