RIN1蛋白是人体内第一个特征性Ras效应蛋白,不仅可以通过调节Ras与Rab5蛋白的结合介导EGFR、TβR等受体的内吞作用,还可以直接激活ABL酪氨酸激酶活性。已有研究发现RIN1在膀胱癌、结肠癌、慢性粒细胞白血病等多种肿瘤的发生发展中发挥了重要作用。本文就此进行简要综述。 RIN1 protein is the first characteristic Ras protein in human. It not only mediates the endocytosis of EGFR, TβR and other receptors by regulating the binding of Ras and Rab5 protein, but also directly activates ABL tyrosine kinase activity. It has been found that RIN1 in bladder cancer, colon cancer, chronic myeloid leukemia and other tumors play an important role in the development. This article gives a brief overview of this.