在盐酸酸性条件下,美洛昔康与高锰酸钾发生化学发光反应,甲醛对此发光体系有强烈的增敏作用。在此基础上,建立了一种快速、准确的测定美洛昔康胶囊含量的流动注射化学发光法。在最佳实验条件下,测得的线性范围为1.0–20.0μg/mL,检测限为25.6ng/mL,相对标准偏差为2.1%。常见药物赋形剂对本法没有干扰,方法用于美洛昔康胶囊含量的测定,结果令人满意。 Under the acidic conditions of hydrochloric acid, meloxicam and potassium permanganate chemiluminescence reaction, formaldehyde on the luminescent system has a strong sensitizing effect. On this basis, a rapid and accurate flow injection chemiluminescence method for the determination of meloxicam capsule was established. Under the optimal experimental conditions, the linear range was 1.0-20.0μg / mL, the detection limit was 25.6ng / mL and the relative standard deviation was 2.1%. The common pharmaceutical excipients did not interfere with this method, the method was applied to the determination of meloxicam capsule, and the results were satisfactory.