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目的观察阿托伐他汀治疗不稳定型心绞痛疗效及其对黏附分子和C反应蛋白的影响。方法将不稳定型心绞痛患者随机分为治疗组和对照组,两组均给予同样的基础治疗,治疗组予以阿托伐他汀,治疗8周后,观察治疗前后心绞痛疗效,黏附分子和C反应蛋白水平变化。结果治疗组在改善心绞痛症状及降低黏附分子和C反应蛋白水平方面均明显优于对照组(P<0.05或P<0.01)。结论阿托伐他汀可能通过抑制斑块内的炎症反应,稳定冠状动脉粥样硬化斑块,从而改善心绞痛临床症状有关。
Objective To observe the effect of atorvastatin on unstable angina pectoris and its effect on adhesion molecules and C-reactive protein. Methods Patients with unstable angina were randomly divided into treatment group and control group. Both groups were given the same basic treatment. The treatment group was treated with atorvastatin. After 8 weeks of treatment, the curative effect of angina pectoris, adhesion molecule and C-reactive protein Horizontal changes. Results The treatment group was significantly better than the control group (P <0.05 or P <0.01) in improving the symptoms of angina and decreasing the levels of adhesion molecules and C-reactive protein. Conclusions Atorvastatin may be related to the improvement of clinical symptoms of angina pectoris by inhibiting inflammatory reaction in plaque and stabilizing coronary atherosclerotic plaque.