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生理学上的一个主要概念认为,使放射性试剂在脑中起定位作用的是血脑屏障.如果一个试剂不是依靠载体蛋白通过血脑屏障,就应以足够的脂溶性形式扩散进入脑中.作者概述了几种有价值的单光子核素标记的脂溶性药物(~(123)I-碘安啡太明、~(123)I-丙二胺、~(201)Tl-二乙基氨荒酸盐及~(99m)Tc-乙基半胱氨酸盐),特别强调了~(99m)Tc进行脑灌注显像的药物性质及其临床用途.大量病例表明,脑病理的所有类型都可以从~(99m)Tc-HMPAO灌注异常中显示出来.该化合物的4.1%在脑中吸收并保持恒定8小时以上,可满足
One of the major physiological concepts is that the blood-brain barrier that directs radioactive agents in the brain should diffuse into the brain in sufficient fat-soluble form if the agent does not rely on the carrier protein to cross the blood-brain barrier. Several valuable single-photon nuclide-labeled lipophilic drugs (~ (123) I-iodophor and ~ (123) I-propanediamine, ~201 Tl-diethylcarbamates (99m) Tc-ethylcysteine), with particular emphasis on the pharmacological properties of brain perfusion imaging with ~ (99m) Tc and its clinical use. A large number of cases indicate that all types of brain pathology can be obtained from ~ (99m) Tc-HMPAO perfusion abnormalities showed that 4.1% of the compound absorbed in the brain and kept constant for more than 8 hours to meet