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目的比较5种新一代抗癫痫药物对成人全面强直阵挛发作单药治疗的保留率。方法选择2010年7月-2011年6月354例确诊为癫痫全面强直阵挛发作患者,分别采用拉莫三嗪、左乙拉西坦、奥卡西平、托吡酯、加巴喷丁5种药物进行单药治疗,对其5种药物的6、12个月保留率进行比较。结果 5种药物的6、12个月保留率分别为:拉莫三嗪90.8%、79.8%,左乙拉西坦88.0%、66.7%,奥卡西平82.1%、58.2%,托吡酯81.2%、58.0%,加巴喷丁26.5%、20.6%。6个月保留率加巴喷丁与其他4种药物比较差异有统计学意义(P<0.001),其他药物之间差异无统计学意义。12个月保留率拉莫三嗪与其他4种药物比较差异有统计学意义(P<0.005),其他药物之间差异无统计学意义。结论拉莫三嗪对成人全面强直阵挛发作单药治疗12个月保留率最高。通过对5种新一代抗癫痫药物12个月保留率比较研究,可以对临床单药治疗癫痫药物选择提供一定参考。
Objective To compare the retention rates of five new-generation antiepileptic drugs in monotherapy with adult tonic-clonus. Methods From July 2010 to June 2011, 354 patients with definite tonic-type seizures were diagnosed as epilepsy. Five patients were treated with lamotrigine, levetiracetam, oxcarbazepine, topiramate, gabapentin, respectively , Compared their 6,12 months retention rate of 5 drugs. Results The retention rates of 6 and 12 months of the five drugs were: lamotrigine 90.8%, 79.8%, levetiracetam 88.0%, 66.7%, oxcarbazepine 82.1%, 58.2%, topiramate 81.2%, 58.0 %, Gabapentin 26.5%, 20.6%. The 6-month retention rate of gabapentin was significantly different from the other 4 drugs (P <0.001), but there was no significant difference between the other drugs. The 12-month retention rate of lamotrigine was statistically different from the other 4 drugs (P <0.005). There was no significant difference between the other drugs. Conclusions Lamotrigine has the highest retention rate at 12 months in monotherapy of adult full tonic. Through the five new generation antiepileptic drugs 12 months comparative study of retention rates, clinical monotherapy for epilepsy drug selection can provide some reference.