Creutzfeldt Jakob病 (CJD)是一种表现为进行性智能减退 ,伴有小脑、锥体系和锥体外系受损的疾病 ,病变范围广泛 ,是一种罕见病。现报告 1例如下。1　病例　女 ,74岁 ,大学教授。因动作迟缓、行为异常、计算及记忆力减退半月余于 2 0 0 0年 3月 5日入院。病程中伴有视物变形、 Creutzfeldt Jakob disease (CJD) is a disease characterized by progressive hypothyroidism with impaired cerebellar, pyramidal and extrapyramidal pathologies, with a wide range of disease and is a rare condition. One report is as follows. 1 case female, 74 years old, university professor. Due to slow movements, abnormal behavior, calculation and memory loss more than half of the month on March 5, 2000 admission. Accompanied by disease during the visual deformation,