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目的观察碘过量摄入对雄性大鼠骨组织的毒性及损伤性作用。方法复制不同剂量的碘过量摄入雄性大鼠动物模型,并设适碘组为对照,分别喂养3、6、12个月,观察实验大鼠离体股骨和腰椎L1-4的骨密度(BMD)及骨组织形态计量学指标变化。结果摄入碘过量3个月时,雄性大鼠股骨下端骨量及骨结构参数与对照组比较差异均无统计学意义;碘过量摄入6个月时,各剂量实验组的大鼠腰椎BMD均显著升高(均P<0．05),骨形态计量学参数表明骨代谢处于旺盛阶段;在碘过量摄入12个月时,各碘过量组均未出现骨量异常改变,但骨结构参数——骨小梁盲端数有显著升高(均P<0．05),提示碘过量导致骨小粱出现断裂,正常的骨组织结构被破坏。结论短期碘过量摄入对雄性大鼠的骨代谢及骨组织结构不会造成严重影响,长期碘过量摄入往往会导致骨结构的破坏,雄性大鼠对碘过量的耐受性是有一定限度的。
Objective To observe the toxic and damaging effects of excessive iodine intake on bone in male rats. Methods Different doses of iodine were used to ingest the animal models of excessive iodine intake in rats. The rats were sacrificed for 3, 6, and 12 months respectively. The bone mineral density (BMD) of isolated rat femur and lumbar vertebra L1-4 were observed ) And bone histomorphometry changes. Results When the iodine intake was excessive for 3 months, there was no significant difference in the femoral bone mass and bone structure between the male rats and the control group. When the iodine intake exceeded 6 months, the lumbar spine BMD (All P <0.05). Bone morphogenetic parameters showed that bone metabolism was in a state of exuberant stage. Abnormal changes in bone mass were observed in all iodine excess groups at 12 months of iodine overdose, but bone structure Parameters - the number of trabeculae blind end were significantly increased (all P <0.05), suggesting that excessive iodine lead to bone sorrows appear broken, the normal structure of the bone is destroyed. Conclusion Short-term excess iodine intake will not have a serious effect on the bone metabolism and bone structure of male rats. Long-term iodine intake may often lead to the destruction of bone structure. There is a certain limit to the tolerance of male rats to iodine excess of.