作者报告抗疟药治疗后的肌病发病率。回顾性复习了1987年1月～1993年4月214例各种风湿病患者使用抗疟药治疗的病历。其中服氯喹187例(87.3％),服羟基氯喹17例(7.9％),不同时期服过两种药者10例(4.6％)。连续治疗12～18个月,平均17个月。其中3例出现肌病。发病率为1/100病人一年(95％可信限为0.2～3)。3例均患类风湿性关节炎,2男1女,年龄分别为40、71和49岁,均接受氯喹治疗12个月,剂量为250mg/d。患者均慢性进行性发病,对称性近端肌无力,主要累及双下肢。症状持续8～12周,平均10周。无 The authors report the incidence of myopathy after antimalarial treatment. Retrospective review of the January 1987 ~ April 1993 214 cases of various rheumatism patients treated with antimalarial medical records. Among them, 187 cases (87.3%) were served chloroquine, 17 cases (7.9%) took hydroxychloroquine and 10 cases (4.6%) took two kinds of medicine at different periods. Continuous treatment of 12 to 18 months, an average of 17 months. Three cases showed myopathy. The incidence is 1 in 100 patients (95% confidence limit 0.2 to 3). All three patients had rheumatoid arthritis, 2 males and 1 females, aged 40, 71 and 49 years old, all receiving chloroquine for 12 months at a dose of 250 mg / d. Patients were chronic progressive disease, symmetrical proximal muscle weakness, mainly involving the lower extremities. Symptoms persist for 8 to 12 weeks, an average of 10 weeks. no