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目的:研究体表胃肠起搏联合多潘立酮治疗餐后不适综合征的疗效。方法:80例餐后不适综合征的患者,随机分为对照组及观察组。对照组40例予以多潘立酮10毫克,三餐前半小时口服;观察组予以多潘立酮10毫克,三餐前半小时口服,同时予以体表胃肠起搏,2次/日,每次45分钟,共2周,采用8导联胃肠电图仪记录患者空腹及进食后的胃电活动,及应用钡条行胃排空试验。分别于治疗前后对其症状、胃肠电图、胃排空情况进行评估。结果:治疗2周后,经胃肠起搏联合多潘立酮治疗的餐后不适综合征患者症状明显改善,较对照组改善更为明显(P<0.05),胃肠起搏治疗后正常胃电节律百分比较对照组显著改善,实验组胃排空率较对照组改善。结论:体表胃肠起搏联合多潘立酮可显著改善餐后不适综合征患者症状、胃电图参数、胃排空情况.
Objective: To study the efficacy of body surface gastrointestinal pacing combined with domperidone in the treatment of post-prandial discomfort syndrome. Methods: Eighty patients with postprandial discomfort syndrome were randomly divided into control group and observation group. In the control group, 40 patients were given domperidone 10 mg orally for half an hour before meals. The observation group was treated with domperidone 10 mg orally for half an hour before meals. The patients were also given gastrointestinal pacing 2 times a day for 45 minutes each for 2 weeks , Using 8-lead gastrointestinal electrograph to record the fasting and gastric electrical activity after eating, and gastric barium using gastric emptying test. Before and after treatment of their symptoms, gastrointestinal electrogram, gastric emptying assessment. Results: After 2 weeks of treatment, symptoms of postprandial discomfort syndrome treated by gastrointestinal pacing combined with domperidone improved significantly (P <0.05), and the percentage of normal gastric electrical rhythm after gastrointestinal pacing Significantly improved compared with the control group, the experimental group gastric emptying rate than the control group improved. Conclusion: Body surface gastrointestinal pacing combined with domperidone can significantly improve the symptoms of postprandial discomfort syndrome, EGG parameters, gastric emptying.