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在肾功能正常病人甲氰咪胍大部分以原药经尿排泄,另一部分约30～40％被代谢。肾功能衰竭时,甲氰咪胍的血浆半衰期延长且与肌酐清除值呈负相关。对严重肾和肝功能不全患者,甲氰咪胍高血药浓度与病人出现严重精神紊乱有关,在老年和肾功能衰竭病人用常量或高剂量甲氰味胍治疗时也可见精神紊乱。本文旨在对肌酐清除率为5～50ml/分的病人使用减低剂量以及对肌酐清除率为50～75ml/分的病人采用常量(1.0gm/天)时的稳态动力学进行研究。选择慢性肾衰竭患者25例,试验前肌酐清除率均
In patients with normal renal function Cimetidine most of the original drug excretion of urine, the other part of about 30 to 40% were metabolized. When renal failure, the plasma half-life of cimetidine prolonged and negatively correlated with creatinine clearance. In patients with severe renal and hepatic insufficiency, high concentrations of cimetidine blood concentration is associated with a severe mental disorder in the patient. Mental disorders are also seen in elderly and patients with renal failure who are treated with constant or high doses of cystine guanidine. This article aims to study the steady-state kinetics of patients who have a creatinine clearance of 5 to 50 ml / min using a reduced dose and a constant (1.0 gm / day) for patients with creatinine clearance of 50 to 75 ml / min. Chronic renal failure in patients with 25 cases, before the test creatinine clearance were