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[目的]探讨血清胱抑素C与尿微量白蛋白/肌酐比值对诊断2型糖尿病早期肾损害患者的临床诊断价值。[方法]选取2009年5月～2010年10月于某院内分泌科住院治疗的2型糖尿病尿蛋白定性试验为阴性患者60例为观察组,选择体检健康人60例作为对照组,分别对两组患者血清胱抑素C与尿微量白蛋白/肌酐比值进行检测,将检测结果进行统计分析。[结果]观察组患者Cys-C与mAlb/Cr检测结果分别为(0.95±0.24)mg/L、(0.75±0.42)mg/mmol,较对照组(1.62±0.34)mg/L、(12.42±10.37)mg/mmol,差异有统计学意义,P﹤0.05。[结论]Cys-C联合mAlb/Cr检测能提高对T2DM早期肾损害诊断的敏感性,具有较高临床意义,值得推广。
[Objective] To explore the clinical value of serum cystatin C and urinary albumin / creatinine ratio in the diagnosis of early renal damage in type 2 diabetic patients. [Methods] From May 2009 to October 2010 in hospital in a department of endocrinology, type 2 diabetes urinary protein qualitative test was negative in 60 cases of observation group, select the physical examination of 60 cases as a control group, respectively, two Serum levels of cystatin C and urine microalbumin / creatinine were measured in the patients and the results were statistically analyzed. [Results] The results of Cys-C and mAlb / Cr in observation group were (0.95 ± 0.24) mg / L and (0.75 ± 0.42) mg / mmol respectively compared with those in control group (1.62 ± 0.34 mg / 10.37) mg / mmol, the difference was statistically significant, P <0.05. [Conclusion] Cys-C combined with mAlb / Cr can improve the sensitivity of early diagnosis of renal damage in T2DM, which is of high clinical significance and worthy of promotion.