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为阐明不同胎龄肺泡表面上皮和气血屏障的发育状况,对24例受精龄为14～40周的人胎肺脏,进行透射电镜观察。胎龄19周时,即可辨认肺泡Ⅰ型上皮细胞和气血屏障。图像分析表明,气血屏障的厚度,随胎龄的增长而变薄。Ⅱ型肺泡上皮细胞,在胎龄20周后逐渐分化,22周时胞质内出现板层小体,小体的截面积随胎龄而增大。本文着重对气血屏障及Ⅱ型上皮细胞的形态变化进行了讨论。
To clarify the developmental status of alveolar surface epithelium and blood-gas barrier at different gestational age, 24 human fetal lungs with fertilization ages of 14-40 weeks were observed by transmission electron microscopy. 19 gestational age, you can identify alveolar type I epithelial cells and blood-barrier. Image analysis showed that the thickness of the blood-brain barrier became thinner as the gestational age increased. Type II alveolar epithelial cells gradually differentiated after 20 weeks of gestation, and lamellar bodies appeared in the cytoplasm at 22 weeks. The cross section of the body increased with gestational age. This article focuses on the blood-barrier and type II epithelial cell morphological changes are discussed.